Agingdoc Podcast - Agingdoc.com Longevity Coaching and Healthspan Consultation

David Barzilai MD PhD

Agingdoc Podcast interviews longevity doctors and geroscientists to find and expedite healthspan and life extension for all.

Host David Barzilai, MD, PhD ("Agingdoc) is medical doctor and founder and CEO of Healthspan Coaching LLC. He serves as a founding lecturer at the Geneva College of Longevity Science. Dr. Barzilai holds a PhD in health services research, with a focus on evidence-based medicine and is a Diplomate of the American Board of Lifestyle Medicine, and precision longevity specialist.

Dr. Barzilai works with agingdoc.com clients to effectively enhance their longevity strategies as complement to the care provided by his clients existing longevity medicine providers, ensuring a comprehensive approach to healthspan.

For those in the longevity space interested in connecting with Dr. Barzilai, he accepts connections on LinkedIn at: https://www.linkedin.com/in/agingdoc

Join over 30,000 followers on X, where Dr. Barzilai's posts the latest circulating articles for the healthy longevity community at: https://x.com/agingdoc1

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Episodios

#4 Aubrey de Grey Part 3
31-01-2024
#4 Aubrey de Grey Part 3
I do one-on one longevity consulting at agingdoc.comHere are the show notes for this episode with Aubrey:#4 Aubrey de Grey 2023 Part 3:If you missed Part 2 of this series with Aubrey de Grey, it is a must listen. This episode builds on its foundation. In Part 2 (last episode) we:a) Compared Aubrey's Robust Mouse Rejuvenation (RMR) predictions from 20 years ago with how we are today,b) Explored how much room relatively more optimized species like humans may have for profoundly extending life vs.in mice.c) looked into the future with new goals for RMR, delving into the rationale for different expectations than we had for the first round of RMR..This Part 3 with Aubrey de Grey builds  on this, and devles into predictions in people Addressed this episode:1. How does one go about making accurate and responsible predictions about anticipated lifespan extension in people?2. What is the framework, and how does making such predictions influence progress in the field. 3. Again, not shy of controversy Aubrey articles his case for justification of making specific predictions, the basis for his timetable in humans, and elaborates on his views on what good science and good science communication should look like in this arena.I hope you are finding these valuable. I created the Agingdoc Podcast series so that specific areas can be more fully addressed for a more sophisticated audience already well-versed in the geroscience and longevity literature.Links:Agingdoc.com ( More info & Longevity Coaching scheduling)Agingdoc Podcast on Youtube (Video)Agingdoc on X (Posts of health articles: some good, some bad, but eclectic & interesting)Agingdoc Longevity Tech interview (about my "big reveal")Lifespan.io talks to AgingdocYoutube Video Bio - As guest on The Sheekey Science Show.
#9 Matt Kaeberlein Part 5 - Barriers to Translation
29-01-2024
#9 Matt Kaeberlein Part 5 - Barriers to Translation
Follow me @agingdoc1 at X (formerly Twitter) and at agingdoc.com where my online calendar is available for one-on-one online audio-zoom health and longevity coaching and consulting.Extensive Show Notes from previous episode #8 with Figures: https://www.barzilaiconsulting.com/rapamycinA few select references from this episode:Successful management of sirolimus toxicity in a hematopoietic stem cell transplant patient using automated red blood cell exchange https://onlinelibrary.wiley.com/doi/10.1111/trf.16064TORC1 inhibition enhances immune function and reduces infections in the elderlyhttps://www.science.org/doi/10.1126/scitranslmed.3009892Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adultshttps://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(20)30011-8/fulltextTargeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trialshttps://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00062-3/fulltextTargeting the biology of aging with mTOR inhibitorshttps://www.nature.com/articles/s43587-023-00416-yagingdoc.comLinks:Agingdoc.com ( More info & Longevity Coaching scheduling)Agingdoc Podcast on Youtube (Video)Agingdoc on X (Posts of health articles: some good, some bad, but eclectic & interesting)Agingdoc Longevity Tech interview (about my "big reveal")Lifespan.io talks to AgingdocYoutube Video Bio - As guest on The Sheekey Science Show.
Episode 8 Matt Kaeberlein Part 4 - Ultra-high Dose Rapamycin Case Report 500 -1000 mg Rapamune
13-01-2024
Episode 8 Matt Kaeberlein Part 4 - Ultra-high Dose Rapamycin Case Report 500 -1000 mg Rapamune
I do more than just one-on-one longevity coaching at agingdoc.comI also bring you here on Youtube and on Twitter @agingdoc1 interesting content pertinent to aging biology, healthy aging, longevity, lifestyle medicine, and more.The video version of this podcast, highly recommended, especially for the first two minutes can be found on YouTube at: https://youtu.be/62nDXSebMoYCome join me by registering for my NUS lecture including Q&A livestream, Jan 20, 2024 06:30 AM in EST (with free question and answer Q & A with reigstration)http://tinyurl.com/yck5x457 https://nus-sg.zoom.us/webinar/register/WN_MPlVUaMiScC_GNh0YIi5sA#/registrationThis episode, Matt Kaeberlein PhD and I discuss case reports by anonymous N1 (validated by myself, "Agingdoc"). In the previous episode generic rapamune dose of 180 mg was discussed.Don't miss extensive rapamycin episode 7  refs /notes at:http://agingdoc.com/rapamycinToday's episode discusses 100 mg generic Rapamune for an effective dose dose of ~500 mg. Subsequent to recording N1 doubled the dose to 200 mg for an effective dose of 1,000 mg which is approximately 100 - 150 x the most common off-label weekly dosing of rapamycin.Potentially life-threatening opportunistic infections is one of a number established serious risks associated with high dose rapamcyin dosing regimens. Should an individual develop a serious infection, systemic rapamycin may worsen prognosis and would be slow to be eliminated during a critical window of the infection.We contrast with prior work by Joan Mannick examining the affect of closely related rapalog everolimus on vaccination immunization, N1 obtained a COVID vaccine booster within 12 hours of a dose of sirolimus of 20 mg.Counter to the hypothesis that a washout is necessary for vaccine amplification N1 had a strong booster effect as judged by titers.N1 also experienced cardiologist confirmed peri- & myocarditis associated with the COVID booster. Whether sirolimus was contributory or alternatively ameliorated it remains a matter of speculation.While these results cannot be generalized  "the exception breaks the rule, and these cases are fodder for hypotheses generation.1. Pharmacotherapy effectively maintained normal lipid and glucose levels.2. High dose physiologically possible in at least one humanIn the context of an academic institution sponsored randomized controlled may be considered, particularly if tissue saturation is more challenging (say, protected areas like the brain or the setting of cancer).3. Suggestive washout may not be needed ResTORbio everolimus immunization RCT protocol, but with no or else a shorter washout period than they employed. Over 200 ng/mL sirolimus Cmax is  the highest I have seen in the setting of Rapamune, but also not as high as one may expect. It may be that elimination is more efficient in humans.Rapamycin extends lifespan or healthspan used off-label in healthy humans, but by contrast significant risk exists. Rigorous evaluation for off-label indications inLinks:Agingdoc.com ( More info & Longevity Coaching scheduling)Agingdoc Podcast on Youtube (Video)Agingdoc on X (Posts of health articles: some good, some bad, but eclectic & interesting)Agingdoc Longevity Tech interview (about my "big reveal")Lifespan.io talks to AgingdocYoutube Video Bio - As guest on The Sheekey Science Show.
#6 Matt Kaeberlein Part 2
07-12-2023
#6 Matt Kaeberlein Part 2
I do more than just one-on-one longevity coaching at agingdoc.comI also bring you here on Youtube and on Twitter @agingdoc1 interesting content pertinent to aging biology, healthy aging, longevity, lifestyle medicine, and more.This "Part 2" is really an outline of what we will cover over this extraordinarily comprehensive deep dive into progress in longevity, paradigms, impact and with special focus on rapamycin.We also cover Matt's lessons during training and what insight they inspired for his future work, the limitations of over-relying on the Hallmarks of Aging, approaches to look beyond them.Listen now, and subscribe (be sure to click that Bell icon too not to miss an episode!) to stay up-to-date in this series of interviews that has a mission to cover unique content not seen on other longevity podcasts.We are just getting started and you are part of this. Send me your comments and proposals for this series to be a gold standard for geroscience interviews.Follow Matt @mkaeberlein on X (I'm @agingdoc1 there) where he maintains up-to-date links to his latest endeavor including at Optispan - https://www.optispan.life/Questions? You can subscribe to my newsletter and submit forms at agingdoc.com Enjoy!DavidLinks:Agingdoc.com ( More info & Longevity Coaching scheduling)Agingdoc Podcast on Youtube (Video)Agingdoc on X (Posts of health articles: some good, some bad, but eclectic & interesting)Agingdoc Longevity Tech interview (about my "big reveal")Lifespan.io talks to AgingdocYoutube Video Bio - As guest on The Sheekey Science Show.
#3 Aubrey de Grey Part 2
21-11-2023
#3 Aubrey de Grey Part 2
@agingdoc [ agingdoc.com longevity coach] interview with Aubrey de Grey, PART 2.This is an interview with Aubrey unlike any other. A great time for both of us.It's a lively deep dive into controversy and Aubrey's rebuttals and paradigms for change.You be the judge:🔑 KEY INTERVIEW MOMENTS BELOW :👇🔎🧐00:00 Setting the stage our deep-dive02:44 Aubrey's 2003 prediction: 20 years ago!05:56 2005: Onslaught of conventional geroscience vs. the SRF paradgim11:37 Why life extension is ethical imperative13:12 We're long lived already, how much can we gain?18:35 Longevity optimism vs. pessimism - basis20:39 Can we be hopeful for long lived organisms like us?21:37 RMR prediction 20 year ago - how are we doing?👆KEY LINKS 👨‍⚕️🔘You can find more about me at http://agingdoc.com🔘There's also a full video biography in my interview with Eleanor Sheekey on her Sheekey Science Show here: https://youtu.be/e_6cvuR2feo🔘And how it all started, basically "project 49" and how @agingdoc1 from X (Twitter) went public was featured by Longevity Technology here:🔘The longevity journey of Agingdoc – from commentary to clinic🔘https://longevity.technology/news/the-longevity-journey-of-agingdoc-from-commentary-to-clinic/1) Keep up with Aubrey at the LEV Foundation: https://www.levf.org/2) Consider signing the Dublin Accord, a MUST read: dublinlongevitydeclaration.orgLinks:Agingdoc.com ( More info & Longevity Coaching scheduling)Agingdoc Podcast on Youtube (Video)Agingdoc on X (Posts of health articles: some good, some bad, but eclectic & interesting)Agingdoc Longevity Tech interview (about my "big reveal")Lifespan.io talks to AgingdocYoutube Video Bio - As guest on The Sheekey Science Show.
#1 Aubrey de Grey 2023 Part 1
05-11-2023
#1 Aubrey de Grey 2023 Part 1
Aubrey de Grey was my very first guest of the Agingdoc Podcast (before I even gave it a name or was known to be the person behind @,agingdoc1 on Twitter / X)  and I think of both Aubrey and Matt Kaeberlein as "Fathers" of the podcast ( with "Mothers to come"). These two were recorded essentially the same time and kicked off this podcast series, each acclaimed for their roles as innovators and thought leaders in the aging biology behind the quest for evidence-based biotechnology healthy longevity interventions.We assume that the listener already knows Aubrey and his work, and wants to dive deeper. This is just the introdurction.... we are only just starting getting warmed up here, so subscribe to pick up the full series where we go deeper and deeper in a lively discussion distinctive of the focus at Agingdoc Podcast on pondering the broadest questions in geroscience and lifestyle medicine today.I made an effort to invite engaging thought leaders in the field and this series from Aubrey de Grey won't dissapoint!#Be sure to keep up with Aubrey at the LEV Foundation: https://www.levf.org/ # More about the podcast:We're all intersted in determining the healthiest habits for longevity, healthy eating and exercise for longevity, and best longevity practices. Aging biology has the potential of gleening insight into these and intervene in potentially more powerful ways as well.The Agingdoc Podcast explores geroscience, longevity, and lifestyle medicine.Love your thumbs-up / likes / subscribes & bell-icon click (that last step means you won't miss those rare episodes when they come up)... and creative ideas.You friendly neighborhood  @agingdoc More about me at http://agingdoc.com Links:Agingdoc.com ( More info & Longevity Coaching scheduling)Agingdoc Podcast on Youtube (Video)Agingdoc on X (Posts of health articles: some good, some bad, but eclectic & interesting)Agingdoc Longevity Tech interview (about my "big reveal")Lifespan.io talks to AgingdocYoutube Video Bio - As guest on The Sheekey Science Show.
#2 Matt Kaeberlein 2023 Part 1
05-11-2023
#2 Matt Kaeberlein 2023 Part 1
Agingdoc interviews Matt KaeberleinWe're just getting warmed up, in this multi-part interview. Matt and I spent 4.5 hours together and I'll be sharing some of the most enlightening moments. Be sure to subscribe not to miss a future release and search for Agingdoc Podcast on Youtube for the best experience:  Video edition at http://youtube.com/@agingdoc#This podcast is primarily aimed at scientists, academics, and audiences following research in geroscience, aging biology, lifestyle medicine and longevity medicine.The interview assumes the listener is already familiar with aging biology. We aim go go deeper than introductory podcasts, broadening discourse beyond the science toward faster progress in better health and life extension for people.Interviews focus on paradigms, frameworks and strategies towards progress in the biology of of extending human lifespan and healthspan: Big picture issues including strategies towards translating this work through the development, validation, and translation of safe and effective gerotherapeutics to all.We're all intersted in determining the healthiest habits for longevity, healthy eating and exercise for longevity, and best longevity practices. Aging biology has the potential of gleening insight into these and intervene in potentially more powerful ways as well.Video edition at http://youtube.com/@agingdocMore about me at  http://agingdoc.comLinks:Agingdoc.com ( More info & Longevity Coaching scheduling)Agingdoc Podcast on Youtube (Video)Agingdoc on X (Posts of health articles: some good, some bad, but eclectic & interesting)Agingdoc Longevity Tech interview (about my "big reveal")Lifespan.io talks to AgingdocYoutube Video Bio - As guest on The Sheekey Science Show.
Who is @agingdoc1?
05-11-2023
Who is @agingdoc1?
🔑Don't miss the footnotes/credit at the bottom!00:00:00 Introduction  @TheSheekeyScienceShow (check out Eleanor's channel!)00:02:17 Eleanor asks: "Who exactly are you?" 🧐00:02:37 What am I going to do [for a career]?! 🥼00:04:51 ME: “I thought a lot of doctors were pretty terrible…”🤯00:05:43 The Biopsychosocial Model. 📖00:06:50 Yes, I wrote to Richard Weindruck about caloric restriction back in college in 1996 🤪00:07:00 High School in 1993: Helping my high school with the internet & my invitatation/talk for the World Futures Conference 🖥️(https://x.com/agingdoc1/status/1722407300516692009 ). Al Gore stood us up😉00:09:20 What's it like to be a "health coach" in longevity medicine?⚕️00:10:19 Dermatology☀️00:11:57 Family & life balance⚖️00:13:17 What is lifestyle Medicine? 🥗00:5:25 Otto Meyerhof (My great-grandfather's cousin who won the Nobel Prize, 1922)🏆00:15:58 "Passion degrees" - MBA and MS in psychology🎓00:17:28 BA in Health and Society and my incredible mentor Ted Brown🏥00:18:32 BS in Cell and Developmental Biology, our bodies are incredible!🧪00:19:11 Working crazy hard in college, Harmit & pre-med stress & triumph😅00:21:26 – My SUPER-embarassing quote (see the 1993 photo: https://twitter.com/agingdoc1/status/1722949696484729079 )🤭00:23:23 Caloric restriction in college🍽️00:23:53 🔎💕My strategy and SECRET PLOT to *woo* my future wife & why I should write a book "having your right brain train your left brain"🧠 [**Must-listen for the romantic**]!😁😉☝️00:31:45 Graduation, woo-woo! 🎉00:32:35 Discovering myself, reinventing myself, and now, "Project 49," my personal moonshot making an impact longevity medicine. 🚀 00:33:45 Why did I join Twitter? [Now "X"], and become "@agingdoc1"?🤔00:34:04 Mentorship Kurt Stange, Duncan Neuhauser, [too many to list not mentioned: Al Rimm, Gregory Cooper, Mendel Singer, Ron Epstein, Kevin Cooper... ] 🙏00:35:00 Co-designing (with Eliot Mostow MPH) an evidence-based medicine, critical appraisal, and epidemiology curriculum for dermatology residents...).📚00:35:20 First class  of a new MD-PhD in Health Services Research. 00:35:38 Coming to Twitter... my deep dive answer.🏊00:39:52 How and agingdoc has Twitter changed over time?⌚00:41:35 Strong belief systems (health cults) on social media😈00:42:43 Social media and controversies😡00:44.28 AgingDocGPT🤖00:47:15 Do I read everything I post?🔖00:50:05 Hype and integrity😇00:55:32 Changing the world together 🌎00:56:30 The future including trepidation 😨"going public, and staying strong💪to fight the good fight (Eleanor interviewed me before my "big reveal!).Reproduced with gracious permission by Eleanor Sheekey @TheSheekeyScienceShow  *** https://www.nobelprize.org/prizes/uncategorized/otto-meyerhof-and-the-physiology-institute-the-birth-of-modern-biochemistry/ 👨Links:Agingdoc.com ( More info & Longevity Coaching scheduling)Agingdoc Podcast on Youtube (Video)Agingdoc on X (Posts of health articles: some good, some bad, but eclectic & interesting)Agingdoc Longevity Tech interview (about my "big reveal")Lifespan.io talks to AgingdocYoutube Video Bio - As guest on The Sheekey Science Show.